I don't think it needs to be radical, but Macca definitely needs to be dropped till he regains his fitness.
He also needs to accept that Grav cannot play as a lone 6, Dom should be starting alongside him most games.
Fullbacks need to take on a slightly more traditional role and provide width. Bradley needs to start at RB, if he doesn't trust Frimpong to start or come on, play Gomez. Reintroduce the press.
Stop with the tactical overhauls when struggling, make smaller changes, try and play people in their preferred positions.