The Athletic article quoted by the AnfieldSector tweet above says they might:
"Part of the plan post-Salah is that Liverpool will have the option of playing a 4-2-2-2 formation with Alexander Isak and Ekitike paired together up front, with Wirtz and Dominik Szoboszlai operating in front of two deeper-lying midfielders.
One of the priorities is to get Isak, Ekitike and Wirtz in the same team regularly. Remarkably, they have played just 88 minutes of football together all season. Isak, currently recovering from a broken leg, is expected to be fit to play some part in the Champions League tie against PSG."